C 2 ,N-dimethylbenzylamine cyclopalladated compounds: evaluation of cytotoxic, mutagenic and antitubercular activities
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چکیده
منابع مشابه
Mutagenic, Anti-Mutagenic and Cytotoxic Activities of Artediffusin (Tehranolide), in vitro, extracted from Artemisia diffusa
Background: Artediffusin is a sesquiterpene lactone with an endoperoxide group which has been isolated from Artemisia diffusa. Artemisia has always been of great botanical and pharmaceutical interest and is useful in traditional medicines for the treatment of a variety of diseases and complaints. The aims of the present study were to evaluate the cytotoxic, mutagenic and anti-mutagenic activiti...
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Phenolic compounds are widely distributed in Nature and act as pharmacologically active constituents in many herbal medicines. They have multiple biological properties, most notably antioxidant, antibacterial and cytotoxic activities. In the present study an attempt to correlate the phenolic composition of leaf, flower and wood extracts of Piper imperiale, with antioxidant, antitubercular and c...
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A series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity and selectivity as compared with current trypanocidal drug, nifurtimox. Compound 4l exhibit higher selectivity than nifurtim...
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Quinolone antibacterials are one of the most important classes of pharmacological agents known as potent inhibitors of bacterial DNA gyrase and topoisomerase IV that efficiently inhibit DNA replication and transcription by generating several double-stranded DNA break. Some quinolone derivatives demonstrated inhibitory potential against eukaryote topoismarase II and substantial dose-dependent cy...
متن کاملmutagenic, anti-mutagenic and cytotoxic activities of artediffusin (tehranolide), in vitro, extracted from artemisia diffusa
background: artediffusin is a sesquiterpene lactone with an endoperoxide group which has been isolated from artemisia diffusa. artemisia has always been of great botanical and pharmaceutical interest and is useful in traditional medicines for the treatment of a variety of diseases and complaints. the aims of the present study were to evaluate the cytotoxic, mutagenic and anti-mutagenic activiti...
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ژورنال
عنوان ژورنال: Medicinal Chemistry Research
سال: 2015
ISSN: 1054-2523,1554-8120
DOI: 10.1007/s00044-015-1339-3